The UTMB Health MyChart Patient Support team is available 24/7 at (409) 772-4278. Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens. P. Younan, M. Iampietro, R. I. Santos, P. Ramanathan, V. L. Popov and A. Bukreyev (2018). (2019) Modified mRNA-based vaccines elicit robust immune responses and protect guinea pigs from Ebola virus disease. Development of mucosal respiratory tract vaccines against filoviruses based on human and non-human paramyxovirus vectors. King, M. L. Fusco, A. I. Flyak, P. A. Ilinykh, K. Huang, B. Gunn, R. N. 218 (Suppl. The article was chosen for UTMB press releases on 05/24/2017. Non-structural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. Virol. (2017). degree in electrical and computer engineering and physics from the University of Florida, Gainesville, FL, USA, in 2013. The NS2 protein of human respiratory syncytial virus suppresses the cytotoxic T cell response as a consequence of suppressing the type I interferon response. J. E. O. Saphire, S. L. Schendel, M. L. Fusco, K. Gangavarapu, B. M. Gunn, A. (2018) Therapeutic human monoclonal antibody MR191against Marburg virus targets a conserved site to block receptor binding. MyChart Use. Multifunctional pan-ebolavirus antibodies recognize a site of broad vulnerability on the ebolavirus glycoprotein. Acad. Alexander Bukreyev's Lab. Lancet. Op zoek naar Compressport Ultra-Trail 180g Racing Hoodie - UTMB 2020 voor heren? USA 104(23):9788-9793. J Biol. Possibility and challenges of conversion of current virus species names to Linnaean Binomials. P. Younan, M. Iampietro and A. Bukreyev (2018). P. L. Collins and A. Bukreyev (2007). Immunity 49(2):363-374. Mire, P.A. Respiratory syncytial virus can tolerate an intergenic sequence of at least 160 nucleotides with little effect on transcription or replication in vitro and in vivo. B. R. West, A. L. B. B. Kimble, D. C. Malherbe, M. Meyer, B. M. Gunn, M. M. Karim, P. A. Ilinykh, M. Iampietro, K. S. Mohamed, S. Negi, P. Gilchuk, K. Huang, Y I. Wolf, W. Braun, J. E. Crowe Jr., G. Alter, A. Bukreyev (2018). Individuals interested in joining the lab as a Research Associate, a Postdoctoral Fellow or a Research Scientist should send a brief email and CV or resume directly to Dr. Bukreyev. A. Kotelkin, I. M. Belyakov, L. Yang, J. Vaccines 1(2):233-245. Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody. Investigation of mechanisms of "immune paralysis" caused by filoviruses. Sci. Chem. 2000 (competitive). A. Bukreyev, B. R. Murphy, and P. L. Collins (2000). Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. Disabling of lymphocyte immune response by Ebola Virus.PLOS Pathogens 14(4):e1006932. National Institute of Allergy and Infectious Diseases Performance Award in Recognition of Special Achievement in Support of the Mission of the National Institute of Allergy and Infectious Diseases. J. Infect. Biol. Ebola Virus Shed GP Triggers Differentiation, Infection and Death of Monocytes Through TLR4 Activation. Dis. J. Virol. Welcome to the Department of Anesthesiology, UTMB Health, J. Virol. C. Le Nouën S. Munir, S. Losq, C. C Winter, T. McCarty, D. A Stephany, K. L Holmes, A. Bukreyev, R. L. Rabin, P. L Collins, and U. J Buchholz (2009). Geisbert, A.B. J. Virol. L. B. The Student Organization of Clinical Laboratory Sciences (SOCLS) is an educational organization that works together to volunteer their time to the community, take part in continuing education opportunities outside the classroom, represent the Clinical Laboratory Science profession, and act with honor, integrity, and respect in all our endeavors. Bombardi, M.E. Z. Wec, P. J. Halfmann, J. M. Brannan, A. S. Herbert, X. Qio et al. The TLR4 antagonist Eritoran protects mice from lethal filovirus challenge. Innate immune response of bat and human cells to filoviruses: commonalities and distinctions. Nature Communications 10 (1):1788. Newcastle disease virus as a vaccine vector for humans. 5): S418-S422. J. Virol. Springer, ISBN 3-211-20671-X. Syst. Natl. Implementation of objective PASC-derived taxon demarcation criteria for official classification of Filoviruses. Comparative immunology of bats as a reservoir of emerging viral infections. N. A. Kuzmina, P. Younan, P. Gilchuk, R. I. Santos, A. I. Flyak, P. A. Ilinykh, K. Huang,   N. M. Lubaki, P. Ramanathan, J. E. Crowe, Jr.and A. Bukreyev (2018). B. 101(26):9804-9809. B. Tigabu, P. Ramanathan, A. Ivanov, X. Lin, P. A. Ilinykh, C. S. Parry, A. N. Freiberg, S. Nekhai and A. Bukreyev (2018). J. Virol. Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. Cell. Review. P. L. Collins, A. Bukreyev, and B. R. Murphy (2008). J. Virol. mBio 8(5) e00845-17. 11(5):108-127. K. A. Dave, E. L. Norris, A. (2017). 79: 13275-13284. 5): S475-S485. P. Younan, M. Iampietro, R. I. Santos, P. Ramanathan, V. L. Popov and A. Bukreyev (2018). Innate immune response of bat and human cells to filoviruses: commonalities and distinctions. Turner, T. Alkutkar, R. Flinko, C. Orlandi, R. Carnahan, R. Nargi, R.G. P. Luthra, S. Aguirre, M. T. Sanchez, B. C. Yen, C. A. Pietzsch, B. Tigabu, L. Morlock, A. Garcia-Sastre, A. Sesma, N. Williams, A. Bukreyev, D. W. Leung, and C. Basler. A. Bukreyev, S. Whitehead, B. Murphy, and P. Collins (1997). Runners' lab is de specialist voor lopers, traillopers en wandelaars. Antibody-mediated protective mechanisms induced by a trivalent parainfluenza-vectored ebolavirus vaccine. Acad. Journal of Infectious Diseases 218 (Suppl. P. A. Ilinykh, Xiaoli Shen, A. I. Flyak, N. Kuzmina, T. G. Ksiazek, J. E. Crowe, Jr., A. Bukreyev. 80:10293-10306. Dis. Topoisomerase II inhibitors induce DNA Damage dependent interferon responses circumventing Ebola virus immune evasion. King, M. L. Fusco, A. I. Flyak, P. A. Ilinykh, K. Huang, B. Gunn, R. N. Recovery of infectious respiratory syncytial virus expressing an additional, foreign gene (1996). Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a non-functional cytotoxic T lymphocyte response following primary infection but not following challenge with wild-type virus. What are the risks - hypothetical and observed - of recombination involving live vaccines and vaccine vectors based on nonsegmented negative strand RNA viruses? The article was chosen for UTMB and the Vanderbilt University press releases on 1/21/2016, and was highlighted in Nature 529, 440. A. I. Flyak, P. A. Ilinykh, C. D. Murin, T. Garron, X. Shen, M. L. Fusco, T. Hashiguchi, Z. Dis. Member of the Filoviridae Study Group of the International Committee on Taxonomy of Viruses, 2012-present. P. Gilchuk, D. Murin, J.C. Milligan, R.W. 5): S475-S485. Ward, A. Bukreyev,* and J. E. Crowe, Jr. (2016) Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection. J. Virol. 93(4): e01845-18. A. Bukreyev, A. Marzi, F. Feldmann, L. Zhang, L. Yang, J. M. Ward, D. Dorward, R. J. Pickles, B. R. Murphy, H. Feldmann, and P. L. Collins (2009). development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. 91(8):e02471-16. P. A. Ilinykh, R. I. Santos, B. M. Gunn, N. A. Kuzmina, X. Shen, K. Huang, P. Gilchuk, A. I. Flyak, P. Younan, G. Alter, J. E. Crowe, Jr., and A. Bukreyev (2018). 217(2):451-455. Disruption of phosphatidylserine synthesis or trafficking reduces infectivity of Ebola virus. A. W. Rimoin, A. Bukreyev*, and J. E. Crowe, Jr*. Virally delivered cytokines alter the immune response to future lung infections. Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. Master of Science in Clinical Laboratory Sciences. Our research includes experiments in a BSL-2 lab and in BSL-4 labs of the Galveston National Laboratory. The article was chosen for UTMB and the Vanderbilt University press releases on 5/26/2015. Shieh,  P. E. Rollin, B. R. Murphy, P. L. Collins, and A. Sanchez (2006). Role of TMEM16F in the incorporation phosphatidylserine into budding ebolavirus virions. Ilinykh, K. Huang, N. Kuzmina, P.X. The article was chosen for Lancet press release on 06/23/04 and the NIH press release on 06/24/04. Cell 164(3): 392-405. Convener of the Filoviruses Workshop, 29th Annual Meeting of American Society for Virology, Montana State University, Bozeman, Montana. Characteristics of Filoviridae: Marburg and Ebola Viruses. A. Harker, D. C. P. Lee, Y. Yamaguchi, B. Wang, A. Bukreyev, P. L. Collins, J. S. Tregoning, and P. J. M. Openshaw. *Co-lead authors. The TLR4 antagonist Eritoran protects mice from lethal filovirus challenge. Ebola binding to Tim-1 on T-Lymphocytes induces a cytokine storm. U. J Buchholz, A. Bukreyev, L. Yang, E. W. Lamirande, B. R. Murphy, K. Subbarao, and P. L Collins (2004). Dive into the research topics where Alexander Bukreyev is active. Family Filoviridae: Classification and features. Mol. S. Netesov, S. Wagener, A. Bukreyev, L. Kolombet, D. Pobedimskaya, R. Hawley, I. Belyakov, Y. Remnev, E. Turin (2010). English-Russian Harmonized Dictionary of Biological Safety and Security. M. Meyer, T. Garron, N. M. Lubaki, C. E. Mire, K. A. Fenton, C. Klages, G. G. Olinger, T. W. Geisbert, P. L. Collins, and A. Bukreyev. A. I. Flyak, X. Shen, C. D. Murin, H. L. Turner, M. L. Fusco, R. Lampley, N. Kose, P. A. Ilinykh, N. Kuzmina, A. Branchizio, H. King, L. Brown, C. Bryan, E. Davidson, B. J. Doranz, J. C. Slaughter, G. Sapparapu, C. Klages, T. G. Ksiazek, E. O. Saphire, A. Wang, J. U. McDonald, Y. Yamaguchi, J. P. Luthra, J. Naidoo, C. A. Pietzsch, M. R. Edwards, S. De, S. Khadka, M. Anantpadma, R. A. Davey, A. Bukreyev, J. M. Ready and C. F. Basler (2018). 125(8): 3241-55. The article was chosen for UTMB press releases on 12/01/2016. 218(Suppl. P. Gilchuk, D. Murin, J.C. Milligan, R.W. 79:1113-1124. Beer, R. Kurth, and A. Bukreyev (1999). Chimeric respiratory paramyxovirus bearing Ebola glycoprotein as a sole envelope protein for prevention of Ebola virus infection. Nonsegmented negative-strand viruses as vaccine vectors. B. More antibody with less antigen: Can immunogenicity of attenuated live virus vaccines be improved? Dive into the research topics where Thomas Ksiazek is active. 75:12128-12140. For additional information regarding laboratory access, training, experiments, please contact Dr. … P. Younan, P. Ramanathan, J. Graber, F. Gusovsky, and A. Bukreyev. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. The article was chosen for American Society of Microbiology and UTMB press releases on 09/26/2017. (2018). Email for more info. (2018). Gunn, A.L. Irma Cisneros, PhD Director, Pathology Imaging Core Lab Email: Phone: (409) 772-3938. M. Meyer, E. Huang, O. Yuzhakov, P. Ramanathan, G. Ciaramella, and A. Bukreyev. A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication. Neutralizing antibodies from human survivors target a conserved site in the ebolavirus glycoprotein HR2/MPER regions. American Society for Virology Program Planning Committee, 2011-2013. Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys. J. Infect. In 2017-2018, UTMB CLS graduates earned 100% ASCP Board of Certification one-year pass rate. The article was chosen for UTMB press release on 05/02/13. Awarded by the Presidium of the Russian Academy of Sciences. Recombinant respiratory syncytial virus (RSV) bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. J. Virol. *Co-corresponding author. Alexander Bukreyev: Associated Profiles ; Professor, Pathology and Microbiology & Immunology, UT Medical Branch at Galveston (409) 772-2829 Web Link Lab Webpage : Ebolavirus, Viruses, Respiratory Syncytial Viruses, Marburgvirus, Vaccines, Human Parainfulenza Virus 3, Viruses, Human Respiratory Syncytial Virus A sensitive in vitro high-throughput screen to identify pan-filoviral replication inhibitors targeting the VP35-NP interface ACS Infectious Diseases, 3(3):190-198. These topic labels come from the works of this person. mBio. Our collaborators include Dr. James Crowe, Jr. (Vanderbilt University), Dr. Erica Ollmann Saphire (La Jolla Institute for Immunology), Dr. Galit Alter (Ragon Institute), Dr. Thomas Geisbert (UTMB), Dr. Raul Andino (UCSF), Moderna, Inc. and other groups. Member of Global Viral Network, 2011-present. Review. 74:11017-11026. Crowe Jr. Mire, P.A. A. Bukreyev, Z. Huang, L. Yang, S. Elankumaran, M. St. Claire, B. R. Murphy, S. K. Samal, and P. L. Collins (2005). Bryan, E. Davidson, B.J. G. K. Amarasinghe, N. A. Ceballos, A. C. Banyard, C. F. Basler, S. Bavari, A. J. Bennett, K. R. Blasdell, T. Briese, A. Bukreyev, Y. Cai, et al. MyChart should only be used for non-urgent matters; it should not be used in emergencies. Multifunctional pan-ebolavirus antibodies recognize a site of broad vulnerability on the ebolavirus glycoprotein. mBio 9(5): e01771-18. Cross, C.E. Taxonomy of the order Mononegavirales: update 2018. Natl. 5): S418-S422. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. J. Virol. As a Clinical Laboratory Scientist, you become a behind-the-scenes detective in the health care industry, accurately and precisely performing laboratory procedures to provide crucial information in diagnosing, preventing, and treating diseases. (2017). 89(17): 8974-81. P. L. Collins, S. S. Whitehead, A. Bukreyev, R. Fearns, M. N. Teng, K. Juhasz, R. M. Chanock, and B. M. Murphy (1999). A. Bukreyev, L. Yang, B. Murphy, and P. Collins (2010). Mol. The University of Texas Medical Branch at Galveston, Graduate Training in Experimental Pathology, Pathology Residency & Fellowship Program, Paul Brindley Distinguished Professorship, Pathology Microscope Imaging Core Laboratory, 2018 DMT Conference UTMB Faculty & Staff Registration, American Society for Virology, Full Member. Mucosal immunization protects monkeys against SARS coronavirus infection. Ebolavirus chimerization for the development of a mouse model for screening of Bundibugyo-specific antibodies. M. Iampietro, R. I. Santos, N. M. Lubaki and A. Bukreyev (2018). Development of therapeutic human monoclonal antibody treatments. See Also: ... hospital-based transfusion services and reference labs. The National Institute of Health Fellows Award for Research Excellence. (2014) A comprehensive proteomic view of responses of A549 cells to human respiratory syncytial virus infection. A. Bukreyev, I. M. Belyakov, G. A.